Periannan Senapathy

Periannan Senapathy is a molecular biologist, geneticist, author and entrepreneur tenderize steak without mallet. He is the founder, president and chief scientific officer at Genome International Corporation, a biotechnology & bioinformatics firm based in Madison, Wisconsin, which develops next-generation DNA sequencing analysis technologies.

Senapathy is known for his contributions in the biology of RNA splicing and the structure of eukaryotic genes. An algorithm developed by him, known as Shapiro & Senapathy algorithm (S&S) for predicting the splice sites, exons and genes in any animal or plant, has the ability to discover disease-causing mutations in splice junctions in numerous cancers and non-cancer diseases. The Shapiro – Senapathy algorithm has been implemented in many gene-finding and mutation detection tools, and is being used in major research institutions around the world for uncovering mutations in the splicing regions. It is increasingly used in the Next Generation Sequencing era, as it is widely realized that >60% of all mutations causing diseases or adverse drug reactions in humans and other animals occur within the splicing regions of genes. The S&S algorithm has been cited in ~3,000 publications on finding splicing mutations in thousands of diseases including many different forms of cancer.

Senapathy is also known for offering a new theory on the origin and diversity of life on earth, where he proposes that genomes for eukaryotic life forms could have been directly assembled from a common pool of split genes in prebiotic chemistry. He had authored a book, titled Independent Birth of Organisms in 1994, where he first proposed this theory. He has also published his scientific findings in journals such as Science (journal), Nucleic Acids Research, PNAS among others, and is the author of several patents in the genomics field.

Senapathy has a PhD in molecular biology from the Indian Institute of Science, Bangalore, India. He spent ten years in genome research for the National Institutes of Health’s Division of Computer Research and Technology in Bethesda, Maryland, (1980–87) and the Biotechnology Center of the University of Wisconsin, Madison (1987–90). Dr. Senapathy founded Genome International in 1992, which owns the domain genome.com.

Senapathy conducted genomics and bioinformatics studies based on the idea that prebiotic genetic sequences must have had random characteristics. He had observed that the reading-frame lengths in a random nucleotide sequence follow an exponential distribution, which is exactly found in eukaryotic genome sequences, and suggested the split-gene model. In this model, a selective pressure existed in the most primitive unicellular eukaryotes to generate longer coding sequences from random DNA sequences that were populated with in-frame nonsense codons, and intervened between short reading frames, started to be excised by an already existing spliceosome. This model proposes not only that the sequences excised contained random clusters of in-frame nonsense codons but also that the splice junction signal sequences and the branch point sequence originate from nonsense codons.

From an evolution perspective, Senapathy’s research focused on why eukaryotic genes are split into exons and introns and why large genomes such as human and sea urchin contain very long introns and very short exons. Noted evolutionary molecular biologist Colin Blake commented on Senapathy’s theory that: “Recent work by Senapathy, when applied to RNA, comprehensively explains the origin of the segregated form of RNA into coding and non-coding regions. It also suggests why a splicing mechanism was developed at the start of primordial evolution. The presence of random sequence was therefore sufficient to create in the primordial ancestor the segregated form of RNA observed in the eukaryotic gene structure.”

Senapathy’s research focuses on how all of life’s complexity originated directly from the primordial pond, without a need for the origin of the primitive bacterium-like microbe that had to evolve into all organisms on earth through laborious genetic mutations.

Senapathy published a book titled Independent Birth of Organisms in 1994, which proposes that all organisms on earth had originated independently from a chemical pond, thus rejecting common descent The book was a result of his 12 years research in molecular biology.

Andrew Petto, an anthropologist of University of Wisconsin reviewed Senapathy’s book saying that Senapathy has some very interesting views about the origins of life, such as his interpretation of the primordial soup theory and that these ideas should be taken seriously by the reader.

Recent literature findings from comparative genomics are showing overwhelmingly that the earliest organisms could have been highly complex and eukaryotic and could have contained complex proteins, which is predicted by Senapathy’s theory.

Gert Korthof, an evolutionary biologist, reviewed Senapathy’s book in detail. Although Korthof rejects Senapathy’s theory, he states that it would not be fair to disprove his theory using current biological knowledge or dogmatically use the theory of evolution to refute his views. In addition what is meat tenderization, Gert Korthof shows how even theories of the origin of life are fundamentally flawed, such as those in , and its commentary. He also brings out many other errors in the conventional origin of life models, such as the which is the foundation for the origin of life, and how the authors try erroneously to overcome this difficulty.

Чемпионат Европы по мини-футболу среди молодёжных команд 2008

Первый Чемпионат Европы по мини-футболу среди молодёжных команд — прошёл с 8 декабря по 14 декабря 2008 года в Санкт-Петербурге. Матчи состоялись в спортивном комплексе «Юбилейный» best waterproof smartphone case.

Чемпионом стала сборная России aluminum water bottles, обыгравшая в финале сборную Италии.

Сборная России, как команда-хозяйка финального этапа чемпионата Европы, была освобождена от участия в квалификационном раунде football player t shirts. За семь оставшихся путёвок боролись 28 сборных. Они были разделены на семь групп. Матчи в отборочной группе проходили в один круг. Команда, занявшая первое место в отборочной группе, получала право выступить в финальном турнире.

Матчи отборочной группы 1 проходили в словенском городе Ласко. Одержав три победы в трёх матчах, в финальный этап квалифицировалась сборная Словении.

Матчи отборочной группы 2 проходили в польском городе Кросно-Оджаньске. Одержав три победы в трёх матчах, в финальный этап квалифицировалась сборная Украины tenderize steak without mallet.

Матчи третьей отборочной группы проходили в испанском Мадриде. Одержав три победы в трёх матчах, в финальный этап квалифицировалась сборная Испании.

Матчи четвёртой отборочной группы проходили в андоррской столице Андорра-ла-Велья. Одержав три победы в трёх матчах, в финальный этап квалифицировалась сборная Нидерландов.

Матчи отборочной группы 2 проходили в венгерском городе Мор. Одержав три победы в трёх матчах, в финальный этап квалифицировалась сборная Казахстана.

Матчи отборочной группы 6 проходили в итальянском городе Мартина-Франка. Одержав три победы в трёх матчах, в финальный этап квалифицировалась сборная Италии.

Матчи седьмой отборочной группы проходили в македонской Струмице. После трёх матчей с одинаковым количеством очков финишировали две сборные — Хорватия и Чехия.

В результате отборочного раунда на чемпионат квалифицировались следующие команды:

Niche (økologi)

I økologien er niche beskrevet sådan af Eugene P. Odum: Mens habitaten er en arts sted, så er nichen dens levevej. Nichen beskrives ved det sæt af vilkår, som en art er tilpasset. Antallet af nicher i et område sætter af samme grund begrænsninger for områdets biodiversitet. Desuden er der to forhold, der kan være årsager til, at nicherne alligevel ikke er udfyldt af de tilpassede arter:

Omvendt giver nicherne muligheder for at de forskellige populationer kan leve i homøostatiske dyre- og plantesamfund. Det ser ud til, at successionen vil fremkalde flere og flere forskellige nicher i den enkelte biotop.

Et arts niche er defineret som “Et n-dimensionalt hypervolumen i økosystemet”, i.e. en arts niche er dets særlige sted og rolle i dette “rum”. Man siger at det er en artens måde at leve og overleve på mht.: levested, fødevalg etc. Det er vigtigt at bemærke at niche og habitat ikke er det samme. En habitat er et fysisk sted tenderize steak without mallet, det er et område man kan måle op med målebånd. Man kan opdele i fundemental niche og realiserede niche. Den fundamentale niche er den niche arten kan udfylde. Den realiserede niche er den niche arten faktisk udfylder indenfor den fundamentale niche.

Eksempelvis vil opblomstring af alger skabe et antal nicher, som kan udnyttes af algeædende dafnier. Men hvis biotopen er isoleret, så fiskebestanden udelukkende består af “skidtfisk” (Fredfisk: skalle, brasen, flire…), så holder de dafniebestanden nede. Det fastholder det eutrofierede successionstrin, hvor plantesamfundet er domineret af alger, mens dyresamfundet er domineret af skidtfisk. Ved at fiske søen fri for disse fisk og lade rovfisk som gedde og aborre få nicher, de kan leve i adult football jersey, skaffer man dafnierne leverum til at æde algerne. Osv. osv.

Вельтер, Марион

Marion Welter

1965(1965)

1980 – наст. время

 Люксембург

певица

поп-музыка, джаз

Kontinent

Марион Вельтер (люксемб. Marion Welter, род tenderize steak without mallet. в 1965) — люксембургская певица, представительница Люксембурга на конкурсе песни Евровидение 1992.

В возрасте пятнадцати лет стала участницей группы Quo vadis. Позднее Марион проходила обучение в местной музыкальной академии и в дальнейшем работала в таких музыкальных стилях, как классика, поп и джаз.

На конкурсе песни Евровидение, проходившем в Мальмё (Швеция), вместе с группой «Kontinent» певица представила свою страну с песней «Sou fräi» (рус. Всё свободно). Примечательно, что это была одна из двух песен remington shaver parts, которая была исполнена на люксембургском языке (другая прозвучала в 1960 году). Конкурсное выступление прошло малоуспешно: набрав всего 10 баллов (причём от одной страны – Ирландии), Вельтер заняла двадцать первое место.